Psoriasis is a non-communicable chronic disease, until recently it was simply considered a skin disease. The particularity of the inflammatory process in certain parts of the skin of psoriasis patients is that the life cycle of normal skin cells is about 30-40 days, while that of psoriasis patients is 4-5 days, that is to say, the skin cells gradually die after 4 days and form spots. Chunky, dry, peeling skin, etc.
Today, the problem of treating this complex and difficult-to-treat disease is not only urgent for dermatologists, many other professional doctors are often involved in determining the cause of psoriasis in patients, and are also directly involved in the complexity of the diseasetreatment. Today, medicine believes that psoriasis is due to the body's systemic failure, not just the skin inflammation process.
Even its name has been changed, and it is now a form of psoriasis. Why is psoriasis a systemic pathology? Because in the patient's body, several different body diseases are found at once-nerve, endocrine, and immunity. In medicine, there are several types of psoriasis, and there are many causes of this disease, mainly theoretical, because there is no convincing evidence to prove these so-called causes, we will consider them in more detail.
Some facts:Psoriasis is not contagious because it is believed to be caused by abnormal functioning of the human immune system (that is, overactive T lymphocytes on the skin). Psoriasis is classified as a genetic disease. One parent has psoriasis. If both parents are 65%, the risk of psoriasis in children is 25%. In addition to genetic factors, the trigger mechanism of psoriasis or recurrence also includes intake of antibiotics, NSAID, B vitamins, stress, alcohol, and skin damage.
Viral theory of the etiology of psoriasis
Many studies conducted in patients with psoriasis have found various changes in peripheral lymph nodes, which may indicate the viral nature of the development of this disease. It is suspected to be a retrovirus that is genetically transmitted through genetic means. It may be one of the causes of psoriasis. However, to prove the nature of the virus originating from psoriasis, it is necessary to identify the virus, isolate it and choose the habitat. So far, no one can do it. at this point.
The fact is that retroviruses have the ability to change the genetic code of the host, they have the ability to synthesize DNA with the help of reverse transcriptase, and form a "false program" in cells that change the human genome. However, it has been established that even if blood is transfused from a psoriasis patient to a healthy person, the infection or spread of the disease has never been noticed. Therefore, the claim about the cause of the psoriasis virus has not been confirmed.
Immune causes of psoriasis
This is one of the generally accepted theories of the etiology of psoriasis, because cellular immune diseases are considered to be the main triggering mechanism of the disease. It has been noticed long ago that in people with genetic susceptibility to psoriasis, if chronic infections (tonsillitis, sinusitis, indicating impaired immunity) appear, it is a factor that causes psoriasis.
When the main foci of psoriasis occurs, medicine also shows that the damage to the epidermis is caused by autoimmune attacks. In a large number of studies on patients with psoriasis, it has been determined that the immune complexes, antibodies, and immunoglobulins that cause Munro microabscesses are abnormal.
In the inflammatory process of activating psoriasis, the hypersensitivity of the skin increases sharply. Therefore, the rash characteristics of psoriasis appear in the place of physical or chemical stimulation. When examining skin scales, antigenic components and autoantibodies against them were found in the blood, but not in healthy people in the skin or blood.
This fact provides a basis for asserting that the autoimmune process plays an important role in the cause of psoriasis. But any process, even immune response, will play a role in the entire system. Therefore, a combination of other factors should be considered, such as endocrine influence, genetic factors, and metabolic disorders.
The infectious theory of the development of psoriasis
More than a hundred years ago, many researchers stubbornly searched for the source of psoriasis, and streptococcus, spirochetes and tinea were considered to be the culprits of this disease. However, after research, none of these pathogenic microorganisms have been found to be the cause of psoriasis.
However, infectious diseases, tonsillitis, and ARVI influenza affect the onset of psoriasis or trigger its first onset, which is especially obvious in the cold season, when the immune system is weakened and patients with psoriasis are often hospitalized.
Some authors believe that the development of psoriasis in the context of acute and chronic infections can be promoted by shifting the focus of infection to the endocrine system and nutritional areas, which will lead to the reconstitution of the body's responsiveness. Usually, that is, in 90% of cases, chronic tonsillitis is accompanied by psoriasis, which confirms the influence of the course of infection and reduced immunity on the development of psoriasis.
In addition, according to many experts, this is an infectious allergen of psoriasis. Its supporters believe that psoriasis is an allergic tissue reaction to viruses, streptococci and their metabolites. However, neither the virus nor the infectious theories have been confirmed.
Genetic causes
This reason is based on family manifestations of psoriasis among close relatives and close relatives. However, psoriasis should not be regarded as a strictly genetic disease, nor should it be regarded as diabetes, cancer, or ischemic heart disease, because psoriasis itself is not hereditary, but merely a genetic predisposition. Yes, 60% of psoriasis patients have ancestors or close relatives who have the disease. If one of the parents is sick, then based on the theoretical possibility, the child's risk of psoriasis will increase by 25%. If both parents are sick, thenUp to 75%.
However, psoriasis is not always the case, the cause is only genetic factors. The disease has recently become very common in clinical practice and does not always directly depend on related susceptibility. In psoriasis, the causes are so many that it is impossible to clearly point out a specific cause. Because the pathogenic factors also violate the metabolism of protein or carbohydrates, as well as the combination of lipids, enzyme metabolism, streptococcal infection foci or viral diseases, changes have taken place.
Metabolic disorders are factors in the development of psoriasis
If we consider the abnormal metabolism of psoriasis, the body temperature of many patients will drop slightly, which is one of the symptoms of slowed metabolism, and the cholesterol content also rises, which indicates that lipid metabolism has changed. In view of the high cholesterol level, many researchers regard psoriasis as the quality of cholesterol and believe that the increase in psoriasis is the initial manifestation of skin diseases, because violation of lipid metabolism will stimulate skin keratinization.
Moreover, in psoriasis, the metabolism of vitamins is disturbed, especially vitamins C, A, B12, and B6, while the content of vitamin C in the skin increases. In addition, the changes in the content of iron, copper and zinc have also been noted, which greatly reduces the adaptability of the human body. Almost 25% of psoriasis patients also suffer from diabetes. However, some researchers believe that this fact is not the cause of psoriasis, but a manifestation of psoriasis.
As the disease progresses, the basal metabolism of psoriasis patients most often increases, and those with reduced metabolism often show hypothyroidism, endocrine glands, and gonadal symptoms. In 60% of psoriasis patients, the averageCarbohydrate metabolism is disturbed. A low-calorie diet or even moderate fasting can reduce the body's self-poisoning. Therefore, a diet that treats psoriasis can improve the patient's condition.
Factors that cause psoriasis
At the current stage of medical research to determine the cause of psoriasis, we can say that this is a systemic disease that often recurs, appears in genetically susceptible people, and is accompanied by the destruction of various metabolisms in the central nervous system.
Pressure
The main causes of the onset of psoriasis and the exacerbation of existing chronic psoriasis are usually stress, psychological trauma, long-term fatigue and nervous tension.
Stress triggers the immune and biochemical reactions that lead to the development of psoriasis. However, on the contrary, sometimes negative emotions help complete the clinical symptoms of psoriasis. According to a survey of patients with psoriasis, this predisposing factor causes the onset of disease in 49% of patients, and recurrence of psoriasis in 41% of patients.
Infectious diseases, vaccination, chronic infection foci
Tonsillitis, sinusitis, sexually transmitted infections, otitis media, etc. , especially highly toxic streptococci are usually detected. For the worsening of the disease, this factor is relevant in 21% of patients, and for the onset of psoriasis, infection is the trigger mechanism in 15% of patients.
Hormonal changes in women
During pregnancy, breastfeeding, menopause or puberty-in 6% of the patients surveyed, this is also the cause of the development of psoriasis.
Injuries, bites, burns
Any damage to the skin-In 12-14% of patients, the appearance of psoriasis is caused by physical damage.
Hypothermia
is the cause or worsening of 5% psoriasis.
Medicines
Such as any type of antibiotics, NSAID. Vitamin therapy-especially vitamin C, B, beta blockers, cytostatics, vaccination, and the use of herbal medicine in treatment-cause 6% of psoriasis episodes.
Food poisoning, the abuse of certain foods
Chocolate, citrus fruits and other products-according to patient surveys, this is the cause of psoriasis in 4% of patients.
drinking
In addition, the provocative factors that cause the inflammatory process to proliferate shorten the remission period and increase the risk of complications, which was shown in 3% of the respondents.
Climate change
High humidity, prolonged exposure to strong ultraviolet radiation, sudden changes in temperature and humidity-cause 2% of patients to get worse.